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Composition |
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Each 5 ml of BOOSTIM BD contains:
Amoxicillin trihydrate Equivalent to amoxicillin … 200 mg
Clavulanate potassium Equivalent to clavulanic acid … 28.5 mg |
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Each tablet of BOOSTIM LB 375 / 625 / 1000 contains:
Amoxicillin trihydrate Equivalent to amoxicillin … 250 / 500 / 875 mg
Clavulanate potassium Equivalent to clavulanic acid … 125 mg
Lactic Acid Bacillus spores … 30 / 60 / 60 million |
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Each vial of BOOSTIM IV 150 / 300 / 600 / 1200 contains:
Amoxicillin trihydrate Equivalent to amoxicillin … 125 / 250 / 500 / 1000 mg
Clavulanate potassium Equivalent to clavulanic acid … 25 / 50 / 100 / 200 mg |
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Therapeutic Indications & Usage |
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BOOSTIM is indicated for the treatment of infections caused by amoxicillin-resistant organisms
producing beta-lactamases sensitive to clavulanic acid: |
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Upper respiratory tract infections, such as sinusitis, recurrent otitis media, tonsillitis.
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Lower respiratory tract infections, such as bronchitis (caused by amoxicillin-resistant beta-lacta-
mases producing Escherichia coli, Hemophilus influenzae and Hemophilus para-influenzae),
bronchopneumonia.
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Genitourinary tract infections, such as cystitis, urethritis, pyelonephritis.
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Skin and soft tissue infections.
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BOOSTIM is also effective in the treatment of infections caused by amoxicillin-sensitive organisms at
the appropriate amoxycillin dosage since in this situation the clavulanic acid component does not
contribute to the therapeutic effect. BOOSTIM IV is additionally useful for surgical prophylaxis. |
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Contraindications |
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BOOSTIM is not advocated for those with a history of hypersensitivity to beta-lactams, e.g. penicillins
and cephalosporins. BOOSTIM is also contraindicated in those with previous history of amoxicillin-
clavulanic acid-associated jaundice / hepatic dysfunction.
BOOSTIM should be avoided if infectious mononucleosis is suspected since the occurrence of a
morbilliform rash has been associated with this condition following the use of amoxicillin. BOOSTIM
should not be used in renal failure when glomerular filtration rate is less than 30 ml/minute. |
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Precautions & Warnings |
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BOOSTIM should be advocated with caution in presence of hepatic dysfunction or renal impairment.
Prolonged use of BOOSTIM BD could result in overgrowth of non-susceptible organisms. |
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Since BOOSTIM contains amoxicillin, an aminopenicillin, it is not the treatment of choice in patients
presenting with sore throat or pharyngitis because of the possibility that the underlying cause is
infectious mononucleosis, in the presence of which there is a high incidence of rash if amoxycillin is
used. |
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Periodic assessment of organ system functions, including renal, hepatic and hematopoietic function, is advisable during prolonged BOOSTIM therapy. BOOSTIM is not ideally meant for pregnant lady or
lactating mother; however, it could be advocated only if strictly necessary. |
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If superinfections occur (usually involving Aerobacter, Pseudomonas or Candida spp), BOOSTIM
should be discontinued and/or appropriate therapy instituted. BOOSTIM must be coadministered with
caution along with probenecid and allupurinol. |
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Since both the 250-mg and 500-mg (amoxicillin) tablets of BOOSTIM LB contain the same amount
of clavulanic acid (125 mg, as the potassium salt), two 250-mg amoxicillin containing tablets of
BOOSTIM LB are not equivalent to one 500-mg (amoxicillin) tablet of BOOSTIM LB; therefore, two
BOOSTIM LB 375 tablets should not be substituted for one tablet of BOOSTIM LB 625. |
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Adverse Reactions |
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The most frequently reported adverse effects with amoxicillin clavulanic acid (BOOSTIM) are indi-
gestion, diarrhea, nausea, vomiting, abdominal pain, skin rashes, urticaria and erythema
multiforme, vaginitis, oral thrush, abnormal taste, headache, dizziness, tiredness and hot flushes. |
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Other side effects attributable to amoxicillin (in BOOSTIM) include hypersensitivity reactions, other
gastrointestinal reactions including superficial tooth discoloration, hepatitis, cholestatic jaundice,
hematologic changes and central nervous system effects including convulsions. Lactobacillus (in BOOSTIM LB) can cause an increase in stomach gas.
BOOSTIM IV can cause sudden signs of allergy such as rash, itching or hives on the skin, swelling of
face, lips, tongue or other parts of the body, shortness of breath, wheezing or troubled breathing.
Rarely headache, dizziness and seizures can occur with BOOSTIM IV. |
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Drug Interaction |
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Probenecid decreases the renal tubular secretion of amoxicillin, but does not affect clavulanic acid
excretion. Concomitant use with BOOSTIM may result in increased and prolonged blood levels of amoxycillin.
The combined administration of allopurinol and ampicillin substantially increases the incidence of skin
rashes and BOOSTIM must be cautiously coadministered with allupurinol. |
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Recommended Dosage & Administration |
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BOOSTIM BD |
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Children |
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To dose as per amoxicillin and clavulanic acid recommendations of 20-40 mg / kg and 5-10 mg /kg
(respectively) per day in two divided doses, or as prescribed. |
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Alternatively,
3-9 mths: 1.25 ml (¼ tsf) BOOSTIM BD Suspension twice daily.
9 mths-2 yrs: 2.5 ml (½ tsf) BOOSTIM BD Suspension twice daily.
2-6 yrs: 5 ml (1 tsf) BOOSTIM BD Suspension twice daily.
7-12 yrs: 10 ml (2 tsf) BOOSTIM BD Suspension twice daily. |
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ADULTS |
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10-20 ml (2-4 tsf) BOOSTIM BD Suspension twice daily, or as prescribed. |
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BOOSTIM LB |
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ADULTS |
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Mild-to-Moderate Infections: 1 BOOSTIM LB 375 tid or 1 BOOSTIM LB 625 Tablet bid,
or as prescribed. |
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Severe Infections: 1 BOOSTIM LB 625 tid or 1 BOOSTIM LB 1000 Tablet bid, or as prescribed. |
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Renal Impairment |
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Glomerular filtration rate of 10-30 ml/min: 1 BOOSTIM LB 375 / 625 bid depending upon the severity
of infection. |
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Hemodialysis: 1 BOOSTIM LB 375 / 625 od depending upon the severity of infection.Or as prescribed. |
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BOOSTIM IV |
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Children
0-3 moths:<4 kgs:30 mg/kg BOOSTIM IV bid;>4 kgs:30 mg/kg BOOSTIM IV tid.
3 moths-12 yrs:30 mg/kg BOOSTIM IV tid. >40 kgs: 1.2 gm BOOSTIM IV tid. Or as prescribed.
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ADULTS
1.2 gm BOOSTIM IV tid, or as prescribed. |
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BOOSTIM IV is to be recommended as long as necessary to clear the infection. It is not advocated for
more than 14 days. |
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Surgical Prophylaxis
<1 hour procedure: 1.2 gm BOOSTIM IV single dose, or as prescribed.
Longer operations: 1.2 gm BOOSTIM IV stat and repeat upto 4 times in 24 hours, or as prescribed.
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Presentation |
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BOOSTIM BD Suspension: Bottles of 30 ml.
BOOSTIM LB 375 Tablets: Blisters of 6s
BOOSTIM LB 625 Tablets: Blisters of 6s
BOOSTIM LB 1000 Tablets: Blisters of 6s
BOOSTIM IV Injection: Vials of 150 mg / 300 mg / 600 mg / 1200 mg. With distilled water
for injection
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