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Composition |
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Each dispersible tablet of Each dispersible tablet of SI-FIXIM 400 DT |
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SI-FIXIM 50 / 100 DT contains: contains: |
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Cefixime trihydrate Cefixime trihydrate |
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Equivalent to anhydrous cefixime |
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… 50 / 100 mg Equivalent to anhydrous cefixime … 400 mg |
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Each tablet of SI-FIXIM Each 5 ml of reconstituted SI-FIXIM Dry |
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200 DT contains: Syrup contains: |
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Cefixime trihydrate Cefixime trihydrate |
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Equivalent to anhydrous Equivalent to anhydrous cefixime … 50 mg |
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cefixime … 200 mg |
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Therapeutic Indications & Usage |
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SI-FIXIM is indicated for the treatment of infections caused by susceptible bacteria: |
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- Upper respiratory tract infections, such as pharyngitis, sinusitis, otitis media, tonsillitis.
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- Lower respiratory tract infections, such as acute bronchitis and acute exacerbation of chronic bronchitis.
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- Uncomplicated urinary tract infections.
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Contraindications |
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SI-FIXIM is not advocated for those with a history of hypersensitivity to beta-lactams, e.g. penicillins and cephalosporins. |
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Precautions & Warnings |
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SI-FIXIM should be advocated with caution in presence of renal impairment or GI disease, particularly colitis. Prolonged use of SI-FIXIM could result in overgrowth of non-susceptible organisms. If superinfections occur (usually involving Aerobacter, Pseudomonas or Candida spp), SI-FIXIM should be discontinued and/or appropriate therapy instituted.
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Periodic assessment of hematopoietic function is advisable during prolonged SI-FIXIM therapy. SI-FIXIM is not ideally meant for pregnant lady or lactating mother; however, it could be only if strictly necessary. Nursing discontinuation temporarily must be considered whilst taking SI-FIXIM. Safety and efficacy of cefixime (SI-FIXIM) in children less than 6 months old have not been established. |
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SI-FIXIM must be coadministered with carbamazepine, warfarin and other anticoagulants. |
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Adverse Reactions |
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The most frequent adverse effect is gastrointestinal (GI) complaints, and diarrhea incidence is 16%. Other side effects include hypersensitivity reactions, liver / renal dysfunction, headaches, dizziness, seizures, hematopoietic changes, genital pruritus, vaginitis, candidiasis. |
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Drug Interaction: |
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Elevated carbamazepine levels occur when cefixime (SI-FIXIM) is coadministered. When given with warfarin / anticoagulants, the prothrombin time is elevated. |
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Recommended Dosage & Administration |
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Adults |
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Susceptible infections: 1 SI-FIXIM 200 Tab / 2 SI-FIXIM 100 DT bid, or 2 SI-FIXIM Tabs od, or as prescribed. |
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Uncomplicated cervical / urethral gonococcal infections: 2 SI-FIXIM Tabs stat, or as prescribed. |
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Children |
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<50 kg: 8 mg/kg/day of SI-FIXIM Suspension / SI-FIXIM 50 / 100 DT either as single dose or in two divided doses. |
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>50 kg: As per adult recommendations of 400 mg/day as single, or in two divided doses. |
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Presentation |
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SI-FIXIM 50 / 100 DT: Blister strips of 10s.
SI-FIXIM 200 DT: Blister strips of 10s.
SI-FIXIM 400 DT : Blister Strip of 10’s
SI-FIXIM Dry Syrup: Bottles of 30 ml. |
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