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Composition |
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Each dispersible tablet of SI-FIXIM 50 / 100 DT
contains: |
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Cefixime trihydrate |
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Equivalent to anhydrous cefixime … 50 / 100 mg |
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Each tablet of SI-FIXIM 200 DT contains: |
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Cefixime trihydrate |
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Equivalent to anhydrous cefixime … 200 mg |
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Each dispersible tablet of SI-FIXIM 400 DT
contains: |
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Cefixime trihydrate |
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Equivalent to anhydrous cefixime … 400 mg |
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Each 5 ml of reconstituted SI-FIXIM Dry Syrup
contains: |
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Cefixime trihydrate |
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Equivalent to anhydrous cefixime … 50 mg |
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Therapeutic Indications & Usage |
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SI-FIXIM is indicated for the treatment of infections caused by susceptible bacteria: |
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- Upper respiratory tract infections, such as pharyngitis, sinusitis, otitis media, tonsillitis.
- Lower respiratory tract infections, such as acute bronchitis and acute exacerbation of chronic
bronchitis.
- Uncomplicated urinary tract infections.
- Uncomplicated gonorrhea.
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Contraindications |
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SI-FIXIM is not advocated for those with a history of hypersensitivity to beta-lactams, e.g. penicillins
and cephalosporins. |
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Precautions & Warnings |
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SI-FIXIM should be advocated with caution in presence of renal impairment or GI disease, particularly
colitis. Prolonged use of SI-FIXIM could result in overgrowth of non-susceptible organisms. If
superinfections occur (usually involving Aerobacter, Pseudomonas or Candida spp), SI-FIXIM should
be discontinued and/or appropriate therapy instituted.
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Periodic assessment of hematopoietic function is advisable during prolonged SI-FIXIM therapy.
SI-FIXIM is not ideally meant for pregnant lady or lactating mother; however, it could be only if strictly
necessary. Nursing discontinuation temporarily must be considered whilst taking SI-FIXIM. Safety and
efficacy of cefixime (SI-FIXIM) in children less than 6 months old have not been established. |
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SI-FIXIM must be coadministered with carbamazepine, warfarin and other anticoagulants. |
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Adverse Reactions |
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The most frequent adverse effect is gastrointestinal (GI) complaints, and diarrhea incidence is 16%.
Other side effects include hypersensitivity reactions, liver / renal dysfunction, headaches, dizziness,
seizures, hematopoietic changes, genital pruritus, vaginitis, candidiasis.
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Drug Interaction |
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Elevated carbamazepine levels occur when cefixime (SI-FIXIM) is coadministered. When given with
warfarin / anticoagulants, the prothrombin time is elevated.
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Absorption of paracetamol from NIMCET Plus is increased by concomitant metoclopramide, and such
other agents. Probenecid can decrease it's clearance, whilst cholestyramine diminishes absorption of
paracetamol (in NIMCET Plus) when coadministered.
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Recommended Dosage & Administration |
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Adults |
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Susceptible infections: 1 SI-FIXIM 200 Tab / 2 SI-FIXIM 100 DT bid, or 2 SI-FIXIM Tabs od, or as
prescribed.
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Uncomplicated cervical / urethral gonococcal infections: 2 SI-FIXIM Tabs stat, or as prescribed. |
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Children |
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<50 kg: 8 mg/kg/day of SI-FIXIM Suspension / SI-FIXIM 50 / 100 DT either as single dose or in two
divided doses. |
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>50 kg: As per adult recommendations of 400 mg/day as single, or in two divided doses. |
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Presentations |
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SI-FIXIM 50 / 100 DT: Blister strips of 10s.
SI-FIXIM 200 DT: Blister strips of 10s.
SI-FIXIM 400 DT : Blister Strip of 10’s
SI-FIXIM Dry Syrup: Bottles of 30 ml.
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